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CELL SIGNALING AND MOLECULAR PHARMACOLOGY LAB
CELL SIGNALING AND MOLECULAR PHARMACOLOGY LAB
GPCR structure and function
Our team seeks to investigate selective ligands of GPCRs in order to uncover cell signaling and physiology, discover GPCRs-based innovative small molecule therapeutics, and build new chemogenetic platform technology using synthetic biology.
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RESEARCH
We employ cell-based assay development, high-throughput screening, ultralarge docking and structural biology to better understand how ligand maintain distinct receptor conformations that induce its physiological effects.
We also use structure-based drug design to computationally screen vast chemical libraries against our structures to discover and create new compounds that may be used to produce improved treatments.
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Integrative research on GPCRs and their specific ligands to examine cell signaling and physiology
Orphan GPCR probe creation for elucidating unique physiological mechanism
Synthetic biology-based chemogenetic platform technology development for in vivo GPCR investigation
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