CELL SIGNALING AND MOLECULAR PHARMACOLOGY LAB
PUBLICATIONS
SELECTED PAPERS
as of 2023. Dec.
Hye Jin Kang#, Takafumi Minamimoto, Jürgen Wess, Bryan L Roth# (#corresponding author)
Yang Yang*, Hye Jin Kang*, Ruogu Gao*, Jingjing Wang, Gye Won Han, Jeffrey F DiBerto, Lijie Wu, Jiahui Tong, Lu Qu, Yiran Wu, Ryan Pileski, Xuemei Li, Xuejun Cai Zhang, Suwen Zhao, Terry Kenakin, Quan Wang, Raymond C Stevens, Wei Peng, Bryan L Roth, Zihe Rao, Zhi-Jie Liu (*equally contributed)
Reed M Stein*, Hye Jin Kang*, John D McCorvy*, Grant C Glatfelter*, Anthony J Jones, Tao Che, Samuel Slocum, Xi-Ping Huang, Olena Savych, Yurii S Moroz, Benjamin Stauch, Linda C Johansson, Vadim Cherezov, Terry Kenakin, John J Irwin, Brian K Shoichet, Bryan L Roth, Margarita L Dubocovich (*equally contributed)
Cao, Can*; Kang, Hye Jin*; Singh, Isha ;Chen, He; Zhang, Chengwei ; Ye, Wenlei; Hayes, Byron; Liu, Jing ; Gumpper, Ryan; Bender, Brian; Slocum, Samuel; Krumm, Brian, Lansu, Katherine; McCorvy, John; Kroeze, Wesley; English, Justin; DiBerto, Jeffrey; Olsen, Reid; Huang, Xi-Ping; Zhang, Shicheng; Liu, Yongfeng ; Kim, Kuglae; Karpiak, Joel ; Jan, Lily; Abraham, Soman; Jin, Jian ; Shoichet, Brian; Fay, Jonathan; Roth, Bryan L. (*equally contributed)
A PROMISING CHEMICAL SERIES OF POSITIVE ALLOSTERIC MODULATORS OF THE Μ-OPIOID RECEPTOR THAT ENHANCE THE ANTINOCICEPTIVE EFFICACY OF OPIOIDS BUT NOT THEIR ADVERSE EFFECTS. NEUROPHARMACOLOGY (2021)
Pryce, K.D.*, Kang, Hye Jin* , Sakloth, F.*, Liu, Y., Khan, S., Toth, K., Kapoor, A., Nicolais, A., Che, T., Qin, L., et al. (*equally contributed)
SELECTIVITY AND EVOLUTIONARY DIVERGENCE OF METABOTROPIC GLUTAMATE RECEPTORS FOR ENDOGENOUS LIGANDS AND G PROTEINS COUPLED TO PHOSPHOLIPASE C OR TRP CHANNELS. JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Kang, Hye Jin; Menlove, Kit; Ma, Jianpeng; Wilkins, Angela; Lichtarge, Olivier; Wensel, Theodore G.
DETERMINANTS OF ENDOGENOUS LIGAND SPECIFICITY DIVERGENCE AMONG METABOTROPIC GLUTAMATE RECEPTORS. JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Kang, Hye Jin; Wilkins, Angela D; Lichtarge, Olivier; Wensel, Theodore G.
PAPERS
As of Dec, 2023
DOCKING FOR EP4R ANTAGONISTS ACTIVE AGAINST INFLAMMATORY PAIN. NATURE COMMUNICATIONS (2023)
Stefan Gahbauer, Chelsea DeLeon, Joao M. Braz, Veronica Craik, Hye Jin Kang, Xiaobo Wan, Xi-Ping Huang, Christian B. Billesbølle, Yongfeng Liu, Tao Che, Ishan Deshpande, Madison Jewell, Elissa A. Fink, Ivan S. Kondratov, Yurii S. Moroz, John J. Irwin, Allan I. Basbaum, Bryan L. Roth & Brian K. Shoichet
NEUROTENSIN RECEPTOR ALLOSTERISM REVEALED IN COMPLEX WITH A BIASED ALLOSTERIC MODULATOR. BIOCHEMISTRY (2023)
Brian E Krumm, Jeffrey F DiBerto, Reid HJ Olsen, Hye Jin Kang, Samuel T Slocum, Shicheng Zhang, Ryan T Strachan, Lauren M Slosky, Anthony B Pinkerton, Lawrence S Barak, Marc G Caron, Terry Kenakin, Bryan L Roth
SYNTHESIS AND CHARACTERIZATION OF 5-(2-FLUORO-4-[11C]METHOXYPHENYL)-2,2-DIMETHYL-3,4-DIHYDRO-2H-PYRANO[2,3-B]PYRIDINE-7-CARBOXAMIDE AS A PET IMAGING LIGAND FOR METABOTROPIC GLUTAMATE RECEPTOR 2, JOURNAL OF MEDICINAL CHEMISTRY (2022)
Gengyang Yuan; Maeva Dhaynaut; Yu Lan; Nicolas J. Guehl; Dalena Huynh; Suhasini M. Iyengar; Sepideh Afsha; Manish Kumar Jain; Julie E. Pickett; Hye Jin Kang; Hao Wang ; Sung-Hyun Moon; Mary Jo Ondrechen; Changning Wang; Timothy M. Shoup; Georges El Fakhri; Marc D. Normandin, and Anna-Liisa Brownell.
Jordi Bonaventura, Juan L Gomez, Meghan L Carlton, Sherry Lam, Marta Sanchez-Soto, Patrick J Morris, Ruin Moaddel, Hye Jin Kang, Panos Zanos, Todd D Gould, Craig J Thomas, David R Sibley, Carlos A Zarate Jr, Michael Michaelides
DESIGN AND DISCOVERY OF A HIGH AFFINITY, SELECTIVE AND Β-ARRESTIN BIASED 5-HT7 RECEPTOR AGONIST. MEDICINAL CHEMISTRY RESEARCH (2022)
Onyameh, E.K., Ofori, E., Bricker, B.A., Gonela, U.M., Eyunni, S.V.K., Kang, Hye Jin, Voshavar, C., and Ablordeppey, S.Y.
SYNTHESIS AND CHARACTERIZATION OF 5-(2-FLUORO-4-[11C]METHOXYPHENYL)-2,2-DIMETHYL-3,4-DIHYDRO-2H-PYRANO[2,3-B]PYRIDINE-7-CARBOXAMIDE AS A PET IMAGING LIGAND FOR METABOTROPIC GLUTAMATE RECEPTOR 2. J. MED. CHEM. (2022)
Gengyang Yuan*, Maeva Dhaynaut, Yu Lan, Nicolas J. Guehl, Dalena Huynh, Suhasini M. Iyengar, Sepideh Afshar, Manish Kumar Jain, Julie E. Pickett, Hye Jin Kang, Hao Wang, Sung-Hyun Moon, Mary Jo Ondrechen, Changning Wang, Timothy M. Shoup, Georges El Fakhri, Marc D. Normandin, and Anna-Liisa Brownell*
Gengyang Yuan, Maeva Dhaynaut, Nicolas J. Guehl, Sepideh Afshar, Dalena Huynh, Sung-Hyun Moon, Suhasini M. Iyengar, Manish Kumar Jain, Julie E. Pickett, Hye Jin Kang, Mary Jo Ondrechen, Georges El Fakhri, Marc D. Normandin, and Anna-Liisa Brownell
SYNTHESIS AND CHARACTERIZATION OF [18F]JNJ-46356479 AS THE FIRST 18FLABELED PET IMAGING LIGAND FOR METABOTROPIC GLUTAMATE RECEPTOR 2. MOLECULAR IMAGING AND BIOLOGY (2021)
Yuan, G., Guehl, N.J., Zheng, B., Qu, X., Moon, S.-H., Dhaynaut, M., Shoup, T.M., Afshar, S., Kang, Hye Jin, Zhang, Z., et al.
DESIGN, SYNTHESIS, AND CHARACTERIZATION OF BENZIMIDAZOLE DERIVATIVES AS POSITRON EMISSION TOMOGRAPHY IMAGING LIGANDS FOR METABOTROPIC GLUTAMATE RECEPTOR 2. JOURNAL OF MEDICINAL CHEMISTRY (2020)
Yuan, G., Qu, X., Zheng, B., Neelamegam, R., Afshar, S., Iyengar, S., Pan, C., Wang, J., Kang, Hye Jin, Ondrechen, M.J., et al.
Krumm, E Brian ; DiBerto,F Jeffrey; Reid HJ Olsen, Kang, Hye Jin ;Samuel T Slocum, Shicheng Zhang, Ryan T Strachan, Xi-Ping Huang, Lauren M Slosky, Anthony B Pinkerton, Lawrence S Barak, Marc G Caron, Terry Kenakin, Jonathan F Fay, Bryan L Roth
SYNTHESIS AND EVALUATION OF A F-18 LABELED TRICYCLIC THIAZOLOPYRAZOLE DERIVATIVE FOR IMAGING OF METABOTROPIC GLUTAMATE RECEPTOR 4 (MGLUR4). JOURNAL OF NUCLEAR MEDICINE (2020)
Wang, Junfeng; Shoup, Timothy; Qu, Xiying; Kang, Hye Jin; Fakhri, Georges El; Zhang, Zhaoda; Brownell, Anna-Liisa.
ZEBRAFISH BEHAVIOURAL PROFILING IDENTIFIES GABA AND SEROTONIN RECEPTOR LIGANDS RELATED TO SEDATION AND PARADOXICAL EXCITATION. NATURE COMMUNICATIONS (2019)
McCarroll, Matthew N; Gendelev, Leo; Kinser, Reid; Taylor, Jack; Bruni, Giancarlo; Myers-Turnbull, Douglas; Helsell, Cole; Carbajal, Amanda; Rinaldi, Capria; Kang, Hye Jin; Gong, Jung Ho; Sello, Jason K; Tomita, Susumu; Peterson, Randall T; Keiser, Michael J; Kokel, David.
EVALUATION OF SYA16263 AS A NEW POTENTIAL ANTIPSYCHOTIC AGENT WITHOUT CATALEPSY. PHARMACOLOGY BIOCHEMISTRY & BEHAVIOR (2019)
Bricker, Barbara A; Peprah, Kwame; Kang, Hye Jin; Ablordeppey, SY.
ISOXAZOLO [3, 4-D] PYRIDAZINONES POSITIVELY MODULATE THE METABOTROPIC GLUTAMATE SUBTYPES 2 AND 4. BIOORGANIC & MEDICINAL CHEMISTRY (2018)
Gates, Christina; Backos, Donald S; Reigan, Philip; Kang, Hye Jin; Koerner, Chris; Mirzaei, Joseph; Natale, NR.
PROTAMINE IS AN ANTAGONIST OF APELIN RECEPTOR, AND ITS ACTIVITY IS REVERSED BY HEPARIN. FASEB J. (2017)
Le Gonidec, Sophie; Chaves-Almagro, Carline; Bai, Yushi; Kang, Hye Jin; Smith, Allyson; Wanecq, Estelle; Huang, Xi-Ping; Prats, H; Knibiehler, Bernard; Roth, Bryan L.
SYNTHESIS AND PRELIMINARY STUDIES OF A NOVEL NEGATIVE ALLOSTERIC MODULATOR [11C] QCA FOR IMAGING OF METABOTROPIC GLUTAMATE RECEPTOR 2. ACS CHEMICAL NEUROSCIENCE (2017)
Zhang, Xiaofei; Kumata, Katsushi; Yamasaki, Tomoteru; Cheng, Ran; Hatori, Akiko; Ma, Longle; Zhang, Yiding; Xie, Lin; Wang, Lu; Kang, Hye Jin; Sheffler, Douglas J.; Cosford, Nicholas D. P.;Zhang, Ming-Rong; Liang, Steven H.
EFFECTS OF KETAMINE AND KETAMINE METABOLITES ON EVOKED STRIATAL DOPAMINE RELEASE, DOPAMINE RECEPTORS, AND MONOAMINE TRANSPORTERS. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2016)
Can, Adem; Zanos, Panos; Moaddel, Ruin; Kang, Hye Jin; Dossou, Katinia SS; Wainer, Irving W; Cheer, Joseph F; Frost, Douglas O; Huang, Xi-Ping; Gould, Todd D.
DEVELOPMENT OF CNS MULTI-RECEPTOR LIGANDS: MODIFICATION OF KNOWN D2 PHARMACOPHORES. BIOORG. MED. CHEM. (2016).
Etukala, Jagan R; Zhu, Xue Y; Eyunni, Suresh VK; Onyameh, Edem K; Ofori, Edward; Bricker, Barbara A; Kang, Hye Jin; Huang, Xi-Ping; Roth, Bryan L; Ablordeppey, Seth Y
DESIGN AND SYNTHESIS OF DUAL 5- HT1A AND 5-HT7 RECEPTOR LIGANDS. BIOORG. MED. CHEM. (2016)
Ofori, Edward; Zhu, Xue Y; Etukala, Jagan R; Peprah, Kwakye; Jordan, Kamanski R; Adkins, Adia A; Bricker, Barbara A; Kang, Hye Jin; Huang, Xi-Ping; Roth, Bryan L.
RE-EXPLORING THE N-PHENYLPICOLINAMIDE DERIVATIVES TO DEVELOP
MGLU4 LIGANDS WITH IMPROVED AFFINITY AND IN VITRO MICROSOMAL STABILITY. BIOORG. MED. CHEM. LETT. (2015)
Zhaoda Zhang, Kun-Eek Kil, Pekka Poutiainen, Ji-Kyung Choi, Hye Jin Kang, Xi-Ping Huang, Bryan L Roth, Anna-Liisa Brownell